Long non-coding RNAs as regulators of the endocrine system

The Role of Long Non-Coding RNAs in Ovarian Cancer

Background: Ovarian cancer is the most fatal tumor of female's reproductive system, and several genetics and environmental factors are involved in its development. Various studies have already identified suitable biomarkers to facilitate the early detection, prognosis evaluation, and the assessment of treatment response. However, the aim of this review was to investigate the role of long non-co...

Long non-coding RNAs as key regulators of cancer metastasis

Long non-coding RNAs as key regulators of cancer metastasis Pratirodh Koirala1, De-Hong Zou2, Yin-Yuan Mo1,3 1Department of Biochemistry and Cancer Institute, University of Mississippi Medical Center, Jackson, MS 39201, USA. 2Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China. 3Department of Pharmacology/Toxicology, University of Mississippi Medical Center, Jackson, ...

Long Non-Coding RNAs as Master Regulators in Cardiovascular Diseases

Cardiovascular disease is the leading cause of death in the United States, accounting for nearly one in every seven deaths. Over the last decade, various targeted therapeutics have been introduced, but there has been no corresponding improvement in patient survival. Since the mortality rate of cardiovascular disease has not been significantly decreased, efforts have been made to understand the ...

Long non-coding RNAs – Novel regulators of the Immune Response?

The Role of Long Non Coding RNAs in the Repair of DNA Double Strand Breaks

DNA double strand breaks (DSBs) are abrasions caused in both strands of the DNA duplex following exposure to both exogenous and endogenous conditions. Such abrasions have deleterious effect in cells leading to genome rearrangements and cell death. A number of repair systems including homologous recombination (HR) and non-homologous end-joining (NHEJ) have been evolved to minimize the fatal effe...